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Article

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.

Cancer research - 1 Dec 2002

Tong Wei-Min, Cortes Ulrich, Hande M Prakash, Ohgaki Hiroko, Cavalli Luciane R, Lansdorp Peter M, Haddad Bassem R, Wang Zhao-Qi

Abstract excerpt

Liver cancer is one of the major human tumors in the world. Basic and epidemiological studies have proposed that the major risk factors for liver cancer include alcohol and diet as well as infection with hepatitis B and C viruses. However, the mechanistic clues for the development of this type of cancer is largely unknown. Poly(ADP-ribose) polymerase (PARP-1) and a component of nonhomologous end-joining (NHEJ)...

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PMID: 12460917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.PMID 12460917Read ↗

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