Article
Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 2012
Eltit Jose Miguel, Bannister Roger A, Moua Ong, Altamirano Francisco, Hopkins Philip M, Pessah Isaac N, Molinski Tadeusz F, López Jose R, Beam Kurt G, Allen Paul D
Abstract excerpt
Malignant hyperthermia (MH) susceptibility is a dominantly inherited disorder in which volatile anesthetics trigger aberrant Ca(2+) release in skeletal muscle and a potentially fatal rise in perioperative body temperature. Mutations causing MH susceptibility have been identified in two proteins critical for excitation-contraction (EC) coupling, the type 1 ryanodine receptor (RyR1) and Ca(V)1.1, the principal...
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