Article
Using the longest significance run to estimate region-specific p-values in genetic association mapping studies.
BMC bioinformatics - 27 May 2008
Lian Ie-Bin, Lin Yi-Hsien, Lin Ying-Chao, Yang Hsin-Chou, Chang Chee-Jang, Fann Cathy S J
Abstract excerpt
BACKGROUND: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increase in the density of available genetic markers, necessitating an increase in the number of association tests required f...
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