Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia.

doi:10.3324/haematol.2022.282542

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia.

Haematologica - 1 Mar 2024

Quinten Edwin, Sepúlveda-Yáñez Julieta H, Koning Marvyn T, Eken Janneke A, Pfeifer Dietmar, Nteleah Valeri, De Groen Ruben A L, Saravia Diego Alvarez, Knijnenburg Jeroen, Stuivenberg-Bleijswijk Hedwig E, Pantic Milena, Agathangelidis Andreas, Keppler-Hafkemeyer Andrea, Van Bergen Cornelis A M, Uribe-Paredes Roberto, Stamatopoulos Kostas, Vermaat Joost S P, Zirlik Katja, Navarrete Marcelo A, Jumaa Hassan, Veelken Hendrik

Abstract excerpt

Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL). The mechanisms driving subclinical MBL B-cell expansion and progression to CLL, occurring in approximately 1% of affected individuals, are unknown. An autonomously signaling B-cell receptor (BCR) is essential for the pathogenesis of CLL. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphocytosis

Share to Mice

Share to Phenotype

Share to Receptors, Antigen, B-Cell

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 37439337
DOI: 10.3324/haematol.2022.282542
PMCID: PMC10905078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia.PMID 37439337Read ↗

Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion.Semantic proximity Read ↗

The molecular map of CLL and Richter's syndromeSemantic proximity Read ↗

Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progressionSemantic proximity Read ↗

Inherited predisposition to chronic lymphocytic leukemia.Semantic proximity Read ↗

Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCLSemantic proximity Read ↗

Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia.Semantic proximity Read ↗

Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia.Semantic proximity Read ↗

General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLLSemantic proximity Read ↗

B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

B-cell receptor signaling in chronic lymphocytic leukemiaSemantic proximity Read ↗

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.