Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset.

Neurobiology of disease - 1 Jul 2008

Panzacchi Andrea, Moresco Rosa Maria, Garibotto Valentina, Antonini Angelo, Gobbo Clara, Isaias Ioannis U, Goldwurm Stefano, Bonaldi Lorena, Carpinelli Assunta, Pezzoli Gianni, Fazio Ferruccio, Perani Daniela

Abstract excerpt

We used positron emission tomography (PET) and the dopamine transporter (DAT) ligand [(11)C]FECIT to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (EOPD) and late onset Parkinson's disease (LOPD). The analysis was carried out with both regions of interest and voxelwise method (SPM2), at group and single subject levels. Genetic analysis tested for the mutations occurring most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Carbon Radioisotopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Plasma Membrane Transport Proteins

Share to Image Processing, Computer-Assisted

Share to Nerve Degeneration

Share to Parkinson Disease

Share to Positron-Emission Tomography

Share to Radiopharmaceuticals

Source

Identifiers

PMID: 18502656
DOI: 10.1016/j.nbd.2008.03.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset.PMID 18502656Read ↗

Striatal dopaminergic denervation in early and late onset Parkinson's disease assessed by PET and the tracer [11C]FECIT: preliminary findings in one patient with autosomal recessive parkinsonism (Park2).Semantic proximity Read ↗

Age at onset and Parkinson disease phenotype.Semantic proximity Read ↗

Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism.Semantic proximity Read ↗

A multitracer dopaminergic PET study of young-onset parkinsonian patients with and without parkin gene mutations.Semantic proximity Read ↗

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease.Semantic proximity Read ↗

Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease.Semantic proximity Read ↗

Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.Semantic proximity Read ↗

The motor phenotype of Parkinson's disease in relation to age at onset.Semantic proximity Read ↗

[Parkinson's disease phenotype based on age at onset in Latin American patients: a paired-based analysis].Semantic proximity Read ↗

The effect of onset age on the clinical features of Parkinson's disease.Semantic proximity Read ↗

Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction.Semantic proximity Read ↗

Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.