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Article

Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2011

Guo Ji-feng, Wang Lei, He Dan, Yang Qiao-hong Ou, Duan Zhong-xiang, Zhang Xue-wei, Nie Li-luo, Yan Xin-xiang, Tang Bei-sha

Abstract excerpt

Mutations in the Parkin, PINK1, and DJ-1 genes can cause autosomal recessive early onset Parkinsonism. We studied three families with the mutations of the Parkin, PINK1 and DJ-1 genes, respectively, with a dopamine transporter ligand [(11)C]-CFT positron emission tomography. A marked bilaterally and dissymmetrically decrement of [(11)C]-CFT uptake was found in all these patients, and putamen as well as caudate...

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Identifiers

PMID: 20607337
DOI: 10.1007/s10072-010-0360-z

Genes

PINK1
PARK7

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