Article
Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins
1 Apr 1991
Abstract excerpt
The herpes simplex virus type 1 genome contains four open reading frames (ORFs) which are predicted to encode hydrophobic proteins with the potential to cross a membrane several times. The products of these genes (genes UL10, UL20, UL43 and UL53) have not previously been identified. To investigate the role of these proteins in the virus life cycle, we attempted to inactivate the genes individually by inserting...
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