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Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes

4 Dec 2008

Abstract excerpt

Information on sites in HSV genomes at which foreign gene(s) can be inserted without disrupting viral genes or affecting properties of the parental virus are important for basic research on HSV and development of HSV-based vectors for human therapy. The intergenic region between HSV-1 UL3 and UL4 genes has been reported to satisfy the requirements for such an insertion site. The UL3 and UL4 genes are oriented...

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PMID: 19302526
DOI: 10.1111/j.1348-0421.2008.00104.x

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