Article
Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons.
Neuron - 1 Dec 1993
Rao M S, Sun Y, Escary J L, Perreau J, Tresser S, Patterson P H, Zigmond R E, Brulet P, Landis S C
Abstract excerpt
Leukemia inhibitory factor (LIF; also known as cholinergic differentiation factor) is a multifunctional cytokine that affects neurons, as well as many other cell types. To examine its neuronal functions in vivo, we have used LIF-deficient mice. In culture, LIF alters the transmitter phenotype of...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Crosses, Genetic
- DNA Primers
- Female
- Galanin
- Ganglia, Sympathetic
- Gene Deletion
- Growth Inhibitors
- Interleukin-6
- Leukemia Inhibitory Factor
- Lymphokines
- Male
- Mice
- Mice, Mutant Strains