Article
Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons.
Neuron - 1 Dec 1993
Rao M S, Sun Y, Escary J L, Perreau J, Tresser S, Patterson P H, Zigmond R E, Brulet P, Landis S C
Abstract excerpt
Leukemia inhibitory factor (LIF; also known as cholinergic differentiation factor) is a multifunctional cytokine that affects neurons, as well as many other cell types. To examine its neuronal functions in vivo, we have used LIF-deficient mice. In culture, LIF alters the transmitter phenotype of sympathetic neurons, inducing cholinergic function, reducing noradrenergic function, and altering neuropeptide...
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