Pleiotropic molecular effects of the<i>Mycobacterium ulcerans</i>virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

Abstract excerpt

Mycolactone is a polyketide macrolide lipid-like secondary metabolite synthesized by Mycobacterium ulcerans, the causative agent of BU (Buruli ulcer), and is the only virulence factor for this pathogen identified to date. Prolonged exposure to high concentrations of mycolactone is cytotoxic to diverse mammalian cells (albeit with varying efficiency), whereas at lower doses it has a spectrum of immunosuppressive...

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