Heterogeneity of Mycolactones Produced by Clinical Isolates of <i>Mycobacterium ulcerans</i> : Implications for Virulence

Abstract excerpt

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a severe necrotizing skin disease endemic in tropical countries. Clinical evidence suggests that M. ulcerans isolates from Asia, Mexico, and Australia may be less virulent than isolates from Africa. In vivo studies suggest that mycolactone, a polyketide-derived macrolide toxin, plays a major role in the tissue destruction and immune suppression which...

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