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Chemistry of mycolactones, the causative toxins of Buruli ulcer

7 Mar 2011

Abstract excerpt

Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis;...

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PMID: 21383136
DOI: 10.1073/pnas.1015252108

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