Article
An RBP4 promoter polymorphism increases risk of type 2 diabetes.
Diabetologia - 1 Aug 2008
van Hoek M, Dehghan A, Zillikens M C, Hofman A, Witteman J C, Sijbrands E J G
Abstract excerpt
AIMS/HYPOTHESIS: Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 -803GA promoter polymorphism influences binding of hepatic nuclear factor 1alpha and is associated with type 2 diabetes in case-control studies. We hypothesised that the RBP4 -803GA polymorphism increases type 2 diabetes risk at a...
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