Article
Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.
Diabetes - 1 Dec 2007
Kovacs Peter, Geyer Michaela, Berndt Janin, Klöting Nora, Graham Timothy E, Böttcher Yvonne, Enigk Beate, Tönjes Anke, Schleinitz Dorit, Schön Michael R, Kahn Barbara B, Blüher Matthias, Stumvoll Michael
Abstract excerpt
OBJECTIVE: Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes. RESEARCH DESIGN AND METHODS: In this study, the RBP4 gene was sequenced in DNA samples from 48 nonrelated Caucasian subjects. Five novel and three known single...
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