Article
Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.
Human genetics - 1 Feb 2007
Munkhtulga Lkhagvasuren, Nakayama Kazuhiro, Utsumi Nanami, Yanagisawa Yoshiko, Gotoh Takaya, Omi Toshinori, Kumada Maki, Erdenebulgan Batmunkh, Zolzaya Khadbaatar, Lkhagvasuren Tserenkhuu, Iwamoto Sadahiko
Abstract excerpt
Increased levels of retinol binding protein 4 (RBP4) in serum is associated with insulin resistance. To examine this further, the genomic region of RBP4 was genetically surveyed in Mongolian people, who as a group are suffering from a recent rapid increase in diabetes. The RBP4 gene was screened by DHPLC system, and the PCR fragments which showed heteroduplex peaks in multiple samples were followed by direct...
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