Article
Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.
Molecular genetics and metabolism - 1 Mar 2007
Craig Rebekah L, Chu Winston S, Elbein Steven C
Abstract excerpt
Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine that reduced peripheral and hepatic insulin sensitivity and increased hepatic gluconeogenesis. The RBP4 gene maps to 10q23-24, near a region linked to T2DM in Caucasian and Mexican American populations. Hence, sequence variants that alter RBP4 expression or function could increase T2DM susceptibility and reduce insulin sensitivity....
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