Article
Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population.
Journal of psychiatry & neuroscience : JPN - 1 May 2009
Zhao Teng, Liu Yun, Wang Peng, Li Sheng, Zhou Daizhan, Zhang Di, Chen Zhuo, Wang Ting, Xu He, Feng Guoyin, He Lin, Yu Lan
Abstract excerpt
BACKGROUND: Bipolar disorder is a widespread and severe brain disorder that is strongly affected by genetic factors. The PDZ and LIM domain 5 (PDLIM5) gene encodes a protein as an Enigma homologue LIM domain protein, which has been widely reported as being expressed in various brain regions. The analysis of DNA microarrays in the frontal lobes of patients with bipolar disorder has indicated changes in the...
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