Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts.

Abstract excerpt

The divergence of new gene functions is described by various scenarios that involve gene duplication, albeit, at fundamentally different stages. We performed experimental measurements and developed a subsequent model, aimed at predicting the rate of divergence under different scenarios. We used gene libraries of TEM-1 beta-lactamase that were drifted under purifying selection toward the original penicillinase...

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