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Article

Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.

Endocrine journal - 1 Aug 2008

Zenibayashi Masako, Miyake Kazuaki, Horikawa Yukio, Hirota Yushi, Teranishi Tetsuya, Kouyama Kunichi, Sakaguchi Kazuhiko, Takeda Jun, Kasuga Masato

Abstract excerpt

AIMS: A missense mutation in the low density lipoprotein receptor-related protein 6 gene (LRP6) was recently shown to be responsible for a disorder characterized by early-onset coronary artery disease as well as diabetes mellitus (DM), hyperlipidemia, hypertension, and osteoporosis. Mice deficient in LRP5, a closely related paralog of LRP6, manifest a marked impairment in glucose tolerance. The aim of the present...

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Source

Identifiers

PMID: 18493104
DOI: 10.1507/endocrj.k08e-021

Genes

LRP6
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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