Article
Cloning of a novel member of the low-density lipoprotein receptor family.
Gene - 17 Aug 1998
Hey P J, Twells R C, Phillips M S, Yusuke Nakagawa, Brown S D, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker M L, Todd J A, Hess J F
Abstract excerpt
A gene encoding a novel transmembrane protein was identified by DNA sequence analysis within the insulin-dependent diabetes mellitus (IDDM) locus IDDM4 on chromosome 11q13. Based on its chromosomal position, this gene is a candidate for conferring susceptibility to diabetes. The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains conserved...
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