Article
Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder.
Haematologica - 1 Jul 2008
Su Xinying, Della-Valle Véronique, Delabesse Eric, Azgui Zahia, Berger Roland, Merle-Béral Hélène, Bernard Olivier A, Nguyen-Khac Florence
Abstract excerpt
Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox transcription factors, TLX1 and TLX3, as frequently ectopically expressed as a result of...
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