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Article

Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes.

Biochemical and biophysical research communications - 8 Nov 2002

Monzen Koshiro, Zhu Weidong, Kasai Hiroki, Hiroi Yukio, Hosoda Toru, Akazawa Hiroshi, Zou Yunzeng, Hayashi Doubun, Yamazaki Tsutomu, Nagai Ryozo, Komuro Issei

Abstract excerpt

A homeobox-containing transcription factor Csx/Nkx2-5 is an important regulator of cardiac development. Many different human CSX/NKX2-5 mutations have been reported to cause congenital heart disease. We here examined the effects of three representative CSX/NKX2-5 mutations on cardiomyocyte differentiation and death with the use of the P19CL6 cardiomyogenic cell lines. Stable overexpression of wild-type CSX/NKX2-5...

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Identifiers

PMID: 12408979
DOI: 10.1016/s0006-291x(02)02497-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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