Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

Nature medicine - 1 Jan 2007

Liu Ting Xi, Becker Michael W, Jelinek Jaroslav, Wu Wen-Shu, Deng Min, Mikhalkevich Natallia, Hsu Karl, Bloomfield Clara D, Stone Richard M, DeAngelo Daniel J, Galinsky Ilene A, Issa Jean-Pierre, Clarke Michael F, Look A Thomas

Abstract excerpt

Interstitial loss of all or part of the long arm of chromosome 5, or del(5q), is a frequent clonal chromosomal abnormality in human myelodysplastic syndrome (MDS, a preleukemic disorder) and acute myeloid leukemia (AML), and is thought to contribute to the pathogenesis of these diseases by deleting one or more tumor-suppressor genes. Although a major commonly deleted region (CDR) has been delineated on chromosome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha Catenin
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HL-60 Cells

Share to Hydroxamic Acids

Share to K562 Cells

Share to Leukemia, Myeloid

Share to Myeloid Progenitor Cells

Share to U937 Cells

Source

Identifiers

PMID: 17159988
DOI: 10.1038/nm1512

Genes

CTNNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.PMID 17159988Read ↗

β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q)Semantic proximity Read ↗

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.Semantic proximity Read ↗

Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31).Semantic proximity Read ↗

A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31.Semantic proximity Read ↗

Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasmsSemantic proximity Read ↗

Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31Semantic proximity Read ↗

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.Semantic proximity Read ↗

Narrowing and genomic annotation of the commonly deleted region of the 5q− syndromeSemantic proximity Read ↗

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disordersSemantic proximity Read ↗

Differential Expression of MicroRNAs in CD34+ Cells of 5q- SyndromeSemantic proximity Read ↗

Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification.Semantic proximity Read ↗

Molecular cytogenetic delineation of the critical deleted region in the 5q− syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.