Article
Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy.
The American journal of surgical pathology - 1 Mar 2013
Antonescu Cristina R, Romeo Salvatore, Zhang Lei, Nafa Khedoudja, Hornick Jason L, Nielsen Gunnlaugur Petur, Mino-Kenudson Mari, Huang Hsuan-Ying, Mosquera Juan-Miguel, Dei Tos Paolo A, Fletcher Christopher D M
Abstract excerpt
Most gastrointestinal stromal tumors (GISTs) can be recognized by their monotonous cytologic features and overexpression of KIT oncoprotein. Altered morphology and loss of CD117 reactivity has been described previously after chronic imatinib treatment; however, this phenomenon has not been reported in imatinib-naive tumors. Eight patients with abrupt transition from a classic CD117-positive spindle cell GIST to...
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