Article
The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region).
Tissue antigens - 1 Dec 2001
Petrone A, Bugawan T L, Mesturino C A, Nisticò L, Galgani A, Giorgi G, Cascino I, Erlich H A, Di Mario U, Buzzetti R
Abstract excerpt
HLA class II is the primary susceptibility gene to type 1 diabetes and the analysis of HLA class II association could help to clarify the relative weight of genetic contribution to the incidence of the disease. Here we present an extensive typing for HLA class II alleles and their haplotypes in a homogenous population of type 1 diabetic patients (n=134) and controls (n=128) and in simplex (n=100) and multiplex...
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