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The Role of HLA Class II Two-Locus Haplotypes and Genotypes in Chinese With Type 1 Diabetes.

Diabetes/metabolism research and reviews - 1 Nov 2025

Liu Jinhan, Luo Shuoming, Xie Zhiguo, Xia Ying, Lin Jian, Huang Gan, Li Xia, Zhou Zhiguang

Abstract excerpt

AIMS: The role of two-locus haplotypes and genotypes of human leucocyte antigen (HLA) class II genes in Chinese type 1 diabetes (T1D) remains unclear. We investigated the susceptibility associated with HLA DR-DQ haplotypes and genotypes in Chinese patients, compared it with that in Caucasians, and analysed the rate of islet autoantibody positivity in T1D patients carrying different susceptible haplotypes....

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Identifiers

PMID: 41204686
DOI: 10.1002/dmrr.70103

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