Article
In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria.
Molecular and cellular biology - 1 Apr 1991
Chomyn A, Meola G, Bresolin N, Lai S T, Scarlato G, Attardi G
Abstract excerpt
A severe mitochondrial protein synthesis defect in myoblasts from a patient with mitochondrial myopathy was transferred with myoblast mitochondria into two genetically unrelated mitochondrial DNA (mtDNA)-less human cell lines, pointing to an mtDNA alteration as being responsible and sufficient fo...
Topics
- Cell Line
- DNA, Mitochondrial
- Electron Transport Complex IV
- Female
- Genotype
- Humans
- Male
- Mitochondria, Muscle
- Muscles
- Muscular Diseases
- Oxygen Consumption
- Pedigree
- Phenotype
- Protein Biosynthesis
- Transfection
- Transformation, Genetic