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Article

Structural and functional relationship of Cassia obtusifolia trypsin inhibitor to understand its digestive resistance against Pieris rapae.

International journal of biological macromolecules - 1 Apr 2020

Zhou Jiayu, Li Chaolin, Chen Anqi, Zhu Jianquan, Zou Meng, Liao Hai, Yu Yamei

Abstract excerpt

Although digestive resistance of Kunitz protease inhibitors has been reported extensively, the molecular mechanism is not well established. In the present study, the first X-ray structure of Cassia obtusifolia trypsin inhibitor (COTI), a member of Kunitz protease inhibitors, was solved at a resolution of 1.9 Å. The structure adopted a classic β-trefoil fold with the inhibitory loop protruding from the hydrophobic...

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PMID: 31981663
DOI: 10.1016/j.ijbiomac.2020.01.193

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