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Article

Tyrosine kinase activating mutations in human malignancies: implications for diagnostic pathology.

Experimental and molecular pathology - 1 Aug 2008

Holden Joseph A, Willmore-Payne Carlynn, Layfield Lester J

Abstract excerpt

Constitutively activated tyrosine kinases play an important role in human malignancies. Their constant downstream signaling leads to cell proliferation and the inhibition of anti-apoptotic mechanisms. New cancer therapeutics have been designed to specifically target the activated kinases in human...

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Source

Identifiers

PMID: 18486128
DOI: 10.1016/j.yexmp.2008.03.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18486128-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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