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Article

Tyrosine kinase activating mutations in human malignancies: implications for diagnostic pathology.

Experimental and molecular pathology - 1 Aug 2008

Holden Joseph A, Willmore-Payne Carlynn, Layfield Lester J

Abstract excerpt

Constitutively activated tyrosine kinases play an important role in human malignancies. Their constant downstream signaling leads to cell proliferation and the inhibition of anti-apoptotic mechanisms. New cancer therapeutics have been designed to specifically target the activated kinases in human cancers and in some instances treatment with these agents leads to tumor regression. With the use of new molecular...

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PMID: 18486128
DOI: 10.1016/j.yexmp.2008.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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