Article
A single-nucleotide polymorphism in the human ITGB3 gene is associated with the platelet-specific alloantigen Va (HPA-17bw) involved in fetal maternal alloimmune thrombocytopenia.
Transfusion - 1 Jul 2008
Stafford Prachi, Garner Stephen F, Rankin Angela, Kekomaki Riitta, Watkins Nicholas A, Ouwehand Willem H
Abstract excerpt
BACKGROUND: The previously reported platelet (PLT)-specific antigen, Va(a), was defined by an alloantibody detected in the serum sample of a mother who delivered an infant displaying symptoms of severe fetal maternal alloimmune thrombocytopenia (FMAIT). This PLT antigen was localized to the integrin alphaIIbbeta3 (GPIIbIIIa) but its genetic basis was not defined. STUDY DESIGN AND METHODS: Genomic ITGA2B...
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