Article
A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.
Transfusion - 1 May 2006
Santoso Sentot, Kroll Hartmut, Andrei-Selmer Cornelia L, Socher Ines, Rankin Angela, Kretzschmar Evelyne, Watkins Nicholas A, Ouwehand Willem H
Abstract excerpt
BACKGROUND: Single-amino-acid substitution Leu33Pro in the beta3-integrin is responsible for the formation of the human platelet antigen (HPA)-1. Alloimmunization against HPA-1a (beta3-Leu33) is the most frequent cause of neonatal alloimmune thrombocytopenia and posttransfusion purpura. STUDY DESIGN AND METHODS: While HPA-1 genotyping a large cohort of patients with thromboembolic disease with a thermal cycler...
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