Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment

22 Dec 2022

Abstract excerpt

FNAIT is a pregnancy-associated condition caused by maternal alloantibodies against paternally-inherited platelet antigens, most frequently HPA-1a on integrin β3. The clinical effects range from no symptoms to fatal intracranial hemorrhage, but underlying pathophysiological determinants are poorly understood. Accumulating evidence suggests that differential antibody-Fc-glycosylation, activation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Cell Adhesion Molecules Research
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36581513
DOI: 10.1016/j.blre.2022.101038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatmentPMID 36581513Read ↗

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrinsSemantic proximity Read ↗

Severe fetomaternal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a in a mother with a rare and silenced ITGB3*0101 (GPIIIa) allele.Semantic proximity Read ↗

Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and managementSemantic proximity Read ↗

Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia.Semantic proximity Read ↗

Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro modelSemantic proximity Read ↗

Antenatal management of fetal and neonatal alloimmune thrombocytopenia: Integration of clinical history and maternal HLA-DRB3*01:01 genotyping in clinical decision-making.Semantic proximity Read ↗

Assessment of human platelet antigen (HPA)-1a alloimmunisation in women identified at increased risk for foetal and neonatal alloimmune thrombocytopaenia (FNAIT): a prospective, natural history studySemantic proximity Read ↗

Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial.Semantic proximity Read ↗

Fetal thrombocytopenia.Semantic proximity Read ↗

Fetoneonatal alloimmune thrombocytopenia (FNAIT): our experience.Semantic proximity Read ↗

Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.