Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.

Cancer cell - 1 Dec 2007

Li Zhe, Tognon Cristina E, Godinho Frank J, Yasaitis Laura, Hock Hanno, Herschkowitz Jason I, Lannon Chris L, Cho Eunah, Kim Seong-Jin, Bronson Roderick T, Perou Charles M, Sorensen Poul H, Orkin Stuart H

Abstract excerpt

To better understand the cellular origin of breast cancer, we developed a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mamm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD24 Antigen
Share to ETS Translocation Variant 6 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Animal

Share to Parity

Share to Proto-Oncogene Proteins c-ets

Share to Proto-Oncogene Proteins c-jun

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 18068631
DOI: 10.1016/j.ccr.2007.11.012
PMCID: PMC2175032

Genes

ETV6
NTRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18068631-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.PMID 18068631Read ↗

<scp>Fusion‐associated</scp>carcinomas of the breast: Diagnostic, prognostic, and therapeutic significanceSemantic proximity Read ↗

Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesisSemantic proximity Read ↗

ETV6-NTRK3—Trk-ing the primary event in human secretory breast cancerSemantic proximity Read ↗

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinomaSemantic proximity Read ↗

Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6-NTRK3 fusion.Semantic proximity Read ↗

ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes.Semantic proximity Read ↗

Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion.Semantic proximity Read ↗

Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in miceSemantic proximity Read ↗

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCCSemantic proximity Read ↗

<i>Brd4::Nutm1</i> fusion gene initiates NUT carcinoma <i>in vivo</i>Semantic proximity Read ↗

Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.Semantic proximity Read ↗

<i>ESR1</i> fusion proteins invoke breast cancer subtype-dependent enrichment of ligand independent pro-oncogenic signatures and phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.