Article
Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.
Cancer research - 15 May 2008
Moore Tricia, Carbajal Steve, Beltran Linda, Perkins Susan N, Yakar Shoshana, Leroith Derek, Hursting Stephen D, Digiovanni John
Abstract excerpt
Calorie restriction has been shown to inhibit epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, including insulin-like growth factor I (IGF-I). Previously, we identified a relationship between elevated tissue IGF-I levels and enhanced susceptibility to chemically induced skin tumorigenesis. In this study, liver IGF-I-deficient (LID) mice, which have a 75%...
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