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Article

A gut feeling of the PXR, PPAR and NF‐κB connection

12 May 2008

Abstract excerpt

Bowel diseases reveal the complex interplay of sensing and signalling pathways in maintaining healthy homeostasis of the intestine. Recent studies of the xenobiotic nuclear receptor, pregnane X receptor and the inflammatory mediator nuclear transcription factor kappaB (NF-kappaB) reveal a functional link between xenobiotic neutralization and inflammation and explain how certain xenobiotics can affect the immune...

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PMID: 18479261
DOI: 10.1111/j.1365-2796.2008.01951.x

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