Article
Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma.
British journal of cancer - 20 May 2008
Engelsen I B, Mannelqvist M, Stefansson I M, Carter S L, Beroukhim R, Øyan A M, Otte A P, Kalland K H, Akslen L A, Salvesen H B
Abstract excerpt
We studied the expression of polycomb group (PcG) protein BMI-1 in a large population-based patient series of endometrial carcinomas in relation to clinical and molecular phenotype. Also, 57 fresh frozen endometrial carcinomas were studied for the relationship between BMI-1 protein expression, BMI-1 mRNA level, and activation of an 11-gene signature reported to represent a BMI-1-driven pathway. BMI-1 protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.