Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.

Abstract excerpt

Patients with von Hippel-Lindau (VHL) disease develop tumors in a range of tissues, but existing mouse models of Vhlh mutation have failed to reproduce these lesions. Epididymal cystadenomas arise frequently in VHL patients, but VHL mutation alone is believed to be insufficient for tumor formation, implying a requirement for cooperating mutations in epididymal pathogenesis. Here we show that epididymal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Deletion
• Share to Genitalia