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Article

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

1 Jun 2008

Abstract excerpt

The ability of cells to escape apoptosis is critical for carcinogenesis as well as resistance to radiation and chemotherapy. ARC (Apoptosis Repressor with CARD (caspase recruitment domain)) is an unusual inhibitor of apoptosis in that it antagonizes both the extrinsic (death receptor) and intrinsic (mitochondrial/ER) apoptosis pathways. ARC is expressed predominantly in terminally differentiated cells such as...

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PMID: 18469522
DOI: 10.4161/cc.7.11.5979

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