Article
Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo.
Apoptosis : an international journal on programmed cell death - 1 Sept 2007
de Bruin Elza C, van de Pas Simone, van de Velde Cornelis J H, van Krieken J Han J M, Peltenburg Lucy T C, Marijnen Corrie A M, Medema Jan Paul
Abstract excerpt
The level of apoptosis in rectal carcinomas of patients treated by surgery only predicts local failure; patients with intrinsically high-apoptotic tumors develop less local recurrences than patients with low levels of apoptosis. To identify genes involved in this intrinsic apoptotic process in vivo, 47 rectal tumors with known apoptotic phenotype (24 low- and 23 high-apoptotic) were analyzed by oligonucleotide...
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