Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML.

Blood - 20 Jan 2011

Carter Bing Z, Qiu Yi Hua, Zhang Nianxiang, Coombes Kevin R, Mak Duncan H, Thomas Deborah A, Ravandi Farhad, Kantarjian Hagop M, Koller Erich, Andreeff Michael, Kornblau Steven M

Abstract excerpt

Regulators of apoptosis in acute myeloid leukemia (AML) have been extensively studied and are considered excellent therapeutic targets. Apoptosis repressor with caspase recruitment domain (ARC), an antiapoptotic protein originally found to be involved in apoptosis of cardiac cells, was recently demonstrated to be overexpressed in several solid tumors. To assess its importance in AML, we profiled ARC expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytarabine

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid

Share to Multivariate Analysis

Share to Muscle Proteins

Share to Oligonucleotides, Antisense

Source

Open in PubMed Open full text

Identifiers

PMID: 21041716
DOI: 10.1182/blood-2010-04-280503
PMCID: PMC3035072

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML.PMID 21041716Read ↗

Identification of a signature based on non-apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia.Semantic proximity Read ↗

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancerSemantic proximity Read ↗

Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nucleiSemantic proximity Read ↗

Activated Intrinsic Apoptosis Pathway Is a Key Related Prognostic Parameter in Acute Myeloid LeukemiaSemantic proximity Read ↗

Long non‑coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemiaSemantic proximity Read ↗

PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemia.Semantic proximity Read ↗

Regulation of p53 tetramerization and nuclear export by ARC.Semantic proximity Read ↗

ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistanceSemantic proximity Read ↗

CDK9 inhibitors in acute myeloid leukemiaSemantic proximity Read ↗

Synergistic Targeting of AML Stem/Progenitor Cells With IAP Antagonist Birinapant and Demethylating AgentsSemantic proximity Read ↗

Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cellsSemantic proximity Read ↗

Expression of DR4, DR5, FAS, Caspase-8 and, DDIAS Genes in AML PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.