Article

Bcl-3 regulates T cell function through energy metabolism

2023-03-21

Abstract excerpt

<h4>Background: </h4> Bcl-3 is a member of the IκB protein family and an essential nuclear factor NF-κB activity modulator. It is well established that Bcl-3 is critical for the normal development, survival and differentiation of adaptive immune cells, especially T cells. However, the regulation of immune cell function by Bcl-3 through metabolic pathways has rarely been studied. <h4>Results: </h4>: In this study,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad4b09be-3d4f-5534-8146-68540f4b00e1
DOI: 10.21203/rs.3.rs-2673008/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bcl-3 regulates T cell function through energy metabolismDOI 10.21203/rs.3.rs-2673008/v1Read

Bcl-2 family proteins: master regulators of cell survivalSemantic proximity Read

Multiple forms of cell death: A focus on the PI3K/AKT pathwaySemantic proximity Read

Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphomaSemantic proximity Read

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.Semantic proximity Read

Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)Semantic proximity Read

[PI3K-AKT network roles in infectious diseases].Semantic proximity Read

The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stressSemantic proximity Read

Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of ageSemantic proximity Read

Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.Semantic proximity Read

PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responsesSemantic proximity Read

A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte FunctionSemantic proximity Read

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug ResistanceSemantic proximity Read