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Article

Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx.

Neuron - 27 Sept 2001

Satterlee J S, Sasakura H, Kuhara A, Berkeley M, Mori I, Sengupta P

Abstract excerpt

Temperature is a critical modulator of animal metabolism and behavior, yet the mechanisms underlying the development and function of thermosensory neurons are poorly understood. C. elegans senses temperature using the AFD thermosensory neurons. Mutations in the gene ttx-1 affect AFD neuron function. Here, we show that ttx-1 regulates all differentiated characteristics of the AFD neurons. ttx-1 mutants are...

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PMID: 11580895
DOI: 10.1016/s0896-6273(01)00431-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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