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Article

Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.

British journal of cancer - 1 Jan 1991

Cunningham J M, Francis G E, Holland M J, Pirollo K F, Chang E H

Abstract excerpt

Inherited susceptibility to a wide variety of neoplasias (Li-Fraumeni syndrome), has been shown in studies of one cancer-prone family, to have an intriguing association with an aberrant c-raf-1 gene and inheritance of a radioresistant phenotype in their non-cancerous skin fibroblasts. This association together with observations that DNA topoisomerases, when defective, can introduce errors into DNA and that these...

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Identifiers

PMID: 1846552
DOI: 10.1038/bjc.1991.8
PMCID: PMC1971654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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