Article
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
British journal of cancer - 1 Jan 1991
Cunningham J M, Francis G E, Holland M J, Pirollo K F, Chang E H
Abstract excerpt
Inherited susceptibility to a wide variety of neoplasias (Li-Fraumeni syndrome), has been shown in studies of one cancer-prone family, to have an intriguing association with an aberrant c-raf-1 gene and inheritance of a radioresistant phenotype in their non-cancerous skin fibroblasts. This associ...
Topics
- Amsacrine
- Ataxia Telangiectasia
- Cell Line
- Cell Nucleus
- Cell Transformation, Neoplastic
- Cytarabine
- Cytoplasm
- DNA Repair
- DNA Topoisomerases, Type II
- DNA, Circular
- DNA, Superhelical
- Female
- Fibroblasts
- Gene Expression
- Genetic Predisposition to Disease
- Humans
- Male
- Neoplasms