Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

6 May 2008

Abstract excerpt

Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood, including type 2 diabetes, and has been proposed to result from altered gene regulation patterns due to epigenetic modifications of developmental genes. To determine whether epigenetic modifications may play a role in the development of adult diabetes following IUGR, we used a rodent model of IUGR that expresses lower...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18464933
DOI: 10.1172/jci33655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1PMID 18464933Read ↗

Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of RatsSemantic proximity Read ↗

Developmental origins of diabetes: the role of epigenetic mechanisms.Semantic proximity Read ↗

Epigenetic Regulation of PDX-1 in Type 2 Diabetes MellitusSemantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem CellsSemantic proximity Read ↗

Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth RestrictionSemantic proximity Read ↗

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded ratSemantic proximity Read ↗

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSemantic proximity Read ↗

IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-γ coactivator-1α in rats.Semantic proximity Read ↗

IGF1 gene is epigenetically activated in preterm infants with intrauterine growth restrictionSemantic proximity Read ↗

Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 PromoterSemantic proximity Read ↗

Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.