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Article

IGF1 gene is epigenetically activated in preterm infants with intrauterine growth restriction

16 Jul 2020

Abstract excerpt

BACKGROUND: IGF1 is a key molecule in the regulation of growth and metabolism. Low IGF1 secretion is known to cause growth restriction in childhood, as well as deregulated lipid metabolism, cardiovascular disease, and diabetes in adulthood. The IGF1 gene P2 promoter is highly methylated, resulting in low secretion of IGF1 in small infants and children. However, it is unknown when this methylation occurs. The aim...

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PMID: 32678007
DOI: 10.1186/s13148-020-00901-w

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