Article
Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus.
International journal of biological sciences - 23 Apr 2008
Jiang Zhihua, Michal Jennifer J, Tobey David J, Wang Zeping, Macneil Michael D, Magnuson Nancy S
Abstract excerpt
Several reports have shown that urotensin 2 (UTS2) and its receptor (UTS2R) are involved in glucose metabolism and insulin resistance, which lead to development of type 2 diabetes mellitus (T2DM) in humans. In the present study, we annotated both bovine UTS2 and UTS2R genes and identified 5 single nucleotide polymorphisms (SNPs) for the former gene and 14 mutations for the latter gene. Four mutations were...
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