Article
Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.
Peptides - 1 Oct 2004
Suzuki Susumu, Wenyi Zong, Hirai Masashi, Hinokio Yoshinori, Suzuki Chitose, Yamada Takahiro, Yoshizumi Shinsuke, Suzuki Michiko, Tanizawa Yukio, Matsutani Akira, Oka Yoshitomo
Abstract excerpt
Urotensin II is among the most potent vasoactive hormones known and the urotensin II (UTS2) gene is localized to 1p36-p32, one of the regions reported to show possible linkage with type 2 diabetes in Japanese. When we surveyed genetic polymorphisms in the UTS2 and urotensin II receptor (GPR14) gene, we identified two SNPs with amino acid substitutions (designated T21M and S89N and an SNP in the promotor region...
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