Article
Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.
Peptides - 1 Jul 2006
Ong Kwok Leung, Wong Louisa Y F, Man Yu Bun, Leung Raymond Y H, Song You-Qiang, Lam Karen S L, Cheung Bernard M Y
Abstract excerpt
We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model...
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