Article
Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis.
Kidney international - 1 Aug 2008
Ichii Osamu, Konno Akihiro, Sasaki Nobuya, Endoh Daiji, Hashimoto Yoshiharu, Kon Yasuhiro
Abstract excerpt
Mag is an MRL-derived glomerulonephritis susceptibility locus that includes the Fcgr2b and Fcgr3 genes encoding the inhibitory Fc gamma receptor IIB (FcgammaRIIB) and active FcgammaRIII, respectively. We measured changes in gene balance in three B6.MRLc1 congenic mouse strains containing the 82-86, 92-100 and 100 cM regions of the MRL chromosome 1. We found that only the strain that has 92-100 (which includes...
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