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Article

Retinoic acid promotes density-dependent growth arrest in human retinal pigment epithelial cells.

Investigative ophthalmology & visual science - 1 Jan 1991

Campochiaro P A, Hackett S F, Conway B P

Abstract excerpt

After retinal detachment the retinal pigment epithelium (RPE) undergoes a striking phenotypic change. It becomes dedifferentiated, proliferates to form multilayered colonies, and migrates into the subretinal space. These processes are important because they have been implicated in proliferative vitreoretinopathy and poor visual recovery after retinal reattachment; however the mechanisms by which they occur are...

Topics

Bucladesine
Cell Count
Cell Differentiation
Cell Division
Cells, Cultured
Humans
Phenotype
Pigment Epithelium of Eye
Retinoids
Thymidine
Tretinoin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1846132

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846132-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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